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Prostaglandin E2 synthase

Prostaglandin E2 synthase (PGES), another member of the MAPEG superfamily, plays a crucial role in infectious and inflammatory processes. The enzyme has been proposed to be a possible target for drug development in the areas of inflammation and possibly cancer [17].

We have recently demonstrated that PGES, overexpressed in and purified from E. coli, can form large and well ordered 2-D crystals (Fig. 2). Like in the case of MGST1 the 2-D crystals are extremely stable and they can be stored for several months at room temperature. Thus it will now also be possible to study this member of the MAPEG family with electron crystallography methods. Preliminary results show that PGES is a trimer with a projection structure similar to that of MGST1.


Last Updated: Friday, January 30, 2004
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